Alkaline Ceramidase Mediates the Oxidative Stress Response in Drosophila melanogaster Through Sphingosine

Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response

Human cells respond to DNA damage by elevating sphingosine, a bioactive sphingolipid that induces programmed cell death (PCD) in response to various forms of stress, but its regulation and role in the DNA damage response remain obscure. Herein we demonstrate that DNA damage increases sphingosine levels in tumor cells by upregulating alkaline ceramidase 2 (ACER2) and that the upregulation of the...

Altered Gravity Induces Oxidative Stress in Drosophila melanogaster

Relationship between gender difference in longevity and oxidative stress response in Drosophila melanogaster

Our results clearly show that Dh pretreatment protected Drosophila from gamma radiation induced lethality (Figure 1) and increased survivability of Dh fed Drosophila compared to control group. Therefore, Dh pretreated flies exhibit more radiation tolerance/resistance than the control flies. Our study demonstrates the radio protective potential of the edible roots of Dh, which has implications i...

Oxidative stress mediates tau-induced neurodegeneration in Drosophila.

Markers of oxidative damage have been detected in brain tissue from patients with Alzheimer disease (AD) and other neurodegenerative disorders. These findings implicate oxidative injury in the neurodegenerative process, but whether oxidative stress is a cause or a consequence of neurotoxicity remains unclear. We used a Drosophila model of human tauopathies to investigate the role of oxidative s...

Oxidative stress resistance: a robust correlated response to selection in extended longevity lines of Drosophila melanogaster?

Stress resistance is associated with longevity in Drosophila melanogaster and other model organisms used for genetic research. The present study tests for oxidative stress resistance in one set of lines selected for late-life reproduction and extended longevity. Both females and males from the selected lines were appreciably more resistant to oxidative stress than were flies from the control li...